System for networked digital pathology exchange

ABSTRACT

A computer-based method and apparatus to facilitate the exchange of pathology studies for the purpose of providing a primary or secondary pathological diagnosis. A study consists of one or more lower-resolution images, the references to the corresponding higher-resolution images, associated image metadata, study metadata and patient metadata. The studies are exchanged from one organization (hospital, practice, or individual physician) to another organization through a set of interconnected dispatcher services. In a cloud model, a plurality of dispatchers may be connected through a Global Dispatcher, both facilitating the addition of new organizations to the cloud and allowing for the addressing of studies from any organization in the cloud to any organization, group or individual in the cloud. By this means, the originating organization may obtain the desired level of care through the selection of recipient organizations, groups and individuals according to the organization&#39;s existing criteria. Efficiency in diagnosis is improved through the addressing of a study to a plurality of qualified recipients, as the first recipient with an appropriate, available resource may review and provide a diagnosis for the study.

RELATED APPLICATION(S)

This application claims the benefit of U.S. Provisional Application No.61/228,819, filed on Jul. 27, 2009. The entire teachings of the aboveapplication(s) are incorporated herein by reference.

FIELD OF THE INVENTION

A method and apparatus to facilitate the exchange of pathology studiesfor the purpose of providing a primary or secondary pathologicaldiagnosis. A study consists of one or more lower-resolution images, thereferences to the corresponding higher-resolution images, associatedimage metadata, study metadata and patient metadata. The studies areexchanged from one organization (hospital, practice, or individualphysician) to another organization through a set of interconnecteddispatcher services. In a cloud model, a plurality of dispatchers may beconnected through a Global Dispatcher, both facilitating the addition ofnew organizations to the cloud and allowing for the addressing ofstudies from any organization in the cloud to any organization, group orindividual in the cloud. By this means, the originating organization mayobtain the desired level of care through the selection of recipientorganizations, groups and individuals according to the organization'sexisting criteria. Efficiency in diagnosis is improved through theaddressing of a study to a plurality of qualified recipients, as thefirst recipient with an appropriate, available resource may review andprovide a diagnosis for the study.

BACKGROUND OF THE INVENTION

The field of Digital Pathology has been recently experiencing anaccelerating growth, and its associated technology is moving towardwidespread adoption. The resulting efficiencies include reduction incost, time, and management overhead associated with traditionalPathology services. The reduction in distribution of glass slidesbetween in-house physicians and external physicians performing secondopinions or referrals is central to the increase in efficiency.Additionally, other associated activities, including searching forslides for publications and presentations are made more efficient whenthe digital form's acquisition and distribution are performed digitallyrather than physically. Logistical efficiencies in the workflow of slideproduction, digitization and immediate archival can relieve the alreadyoverburdened health care facilities and provide a multitude ofadditional capacity and services as well. Finally, as there is no singlephysical piece of media to be viewed, an individual image or study canbe accessed simultaneously by multiple local or remote users.

At the time of this filing, there are five characteristic DigitalPathology scenarios that serve to clearly define how Digital Pathologyis being deployed and planned. These five scenarios are: Stand AloneOrganizations, Expanding Primary Opinion Networks, Point-to-Point SecondOpinion Networks, Peer Networks, and Cloud Networks. The Stand Alonescenario is primarily concerned with the intra-organization efficienciesof digitizing slides and archiving slides for in house pathologyservices. In the Expanding scenario, the health facility is looking toaugment or outsource their own pathology services to a secondorganization, facility or expert center offering external pathologyservices, possibly obviating the requirement for intra-organizationalpathology services, and leveraging the Digital Pathology System of thesecond organization. The Point-to-Point scenario is a dedicated secondopinion or subspecialty service provided by a second organization to afirst organization, where the first organization still maintains its ownDigital Pathology System. The Peer-base scenario defines two or moreorganizations that leverage each of their Digital Pathology services toprovide both combined primary and direct secondary pathology services toboth organizations. The Cloud Network scenario is more of a speculativescenario where global pathology services can be leveraged by anorganization in order to leverage efficiencies of scale without a directlinear relationship of that scaling to cost.

Stand Alone Organizations

For a digital pathology solution inside of an organization (Inside anorganization does not denote network topology as much as all personnelaccessing the digital pathology system have network credentials and canaccess the system either directly or through existing hospital securityinfrastructure) digital pathology applications (including triage,reports generation and primary diagnostic viewing) can be achievedthrough a direct connection to the deployed metadata & imaging services(see Architecture 1). In this case, because the pathologist is directlyrelated to the organization requesting the diagnosis, the pathologistwould have access to all of the patient data available via the metadataservices, so no summarization, reduction or filtering of metadata isrequired. Also, because of the low utilization (an image is likely to betriaged, diagnosed and reported only once), caching or generation ofpreview images (a low- or mid-resolution image to be used during thetriage, assignment and reporting processes) for some stages of theworkflow are not necessary.

Expanding Primary Opinion Networks

In many remote areas of both the United States and the rest of theworld, Pathology Service is still provided by travelling pathologistswho cover a group of associated or independent hospitals by travellingbetween them. In this instance, the highest priced resource in thenetwork is being moved from point-to-point through the network, withsignificant portions of their time being consumed by travel.Alternatives are to ship the slides to be read to a hospital withpathology services. The downside of this method is that slides are oftenlost or broken in the two-way transit from source to pathology resource,and this does not provide for rapid diagnostic ability. Extending thebounds of a pathology department's primary diagnostic ability to includeremote hospitals that are either under-staffed or do not have the properspecialties is the next major arena for networked pathology.

Image previews first come into play in the case where remote digitizersare deployed to affiliated hospitals where no primary pathology serviceexists, the primary organization is performing the primary diagnosticservice, expanding the effective footprint for the primary organization.In this case, all of the metadata and patient details are entered (orimported) into the primary organization's metadata services, as this isthe primary patient record for the pathology system. The images, whichexist at the remote location, will have a preview image created (whichwill be cached at the primary organization) for the triage, assignmentand reporting processes. Only during the actual primary diagnosis of theimage will the full resolution images be accessed from the remote site.

Point-to-Point Second Opinion Networks

The easy first step towards a networked telepathology solution is theaddition of a dependent second organization to provide second opinionson cases. The metadata and image data are retrieved in the same manneras with a primary organization's diagnosis, and the nature of thedependent second organization (a dependent secondary organization doesnot require any hardware or software to enable their diagnosticabilities, thus they do not have a hardware of software footprint towhich info can be cached) does not require or provide an efficientopportunity to cache either a preview image or metadata that wouldrepresent a lower-cost (from a network consumption perspective) solutionthan fetching the data directly from the primary organization's systemas needed. This methodology is equivalent to providing limited networkcredentials and/or providing point-to-point secure network access to anyperson or organization providing second opinions to the primaryinstitution.

Once the scope of a pathology solution expands beyond the bounds of asingle organization with a single physical footprint, some level of dataand/or image caching can be effective in reducing server load andbandwidth required to deploy an effective digital pathology system.

Peer Networks

A Peer Network scenario differs from the Primary/Dependent scenario bythe fact that both organizations have a networked digital pathologysystem, and those systems can exchange studies. Cached metadata becomeuseful and, coupled with a preview image, form a package which can beforwarded to a stand-alone peer system at a second organization. Thefirst architecture requiring the forwarding of packages is the peerorganization model, where two organizations (each is an independentorganization with their own digital pathology solution) can be directlyconnected to one another and exchange studies (a package consisting ofpreview images, the study-specific metadata and security tokens foraccessing the full image) for second opinions or consultation. Directlyconnecting the two organizations involves establishing network links andexchanging security certificates, and allows for the trusted exchange ofinformation. Once connected, studies are directly assigned from oneorganization to another, and the queue of studies to be processed is thecombination of all studies from the primary organization and all studieswhich have been referred to it by peer organization(s).

Cloud Networks

The evolution of networked pathology services is the cloud model. In thecloud model, studies are not directly assigned to an organization, butinstead are made available to a specified group of recipients for secondopinion. In the cloud model, the package is similarly made up of previewimages, study-specific metadata and, instead of security tokens, a listof authorized recipients. The recipients may represent individualdoctors, well known groups of doctors or other organizations. When amember of the recipient list views and accepts the study, that recipienthas claimed the study and it is no longer available to the otherrecipients (first come, first served). This provides the quickestpossible diagnosis for the study from the list of acceptableorganizations and individuals, and will lead to the creation of ‘expertgroups’.

SUMMARY OF THE INVENTION

The invention facilitates the exchange of studies (FIG. 1-105) betweentwo or more organizations (FIG. 2, element 230), each potentially withtheir own digital pathology systems. Each study may consist of one ormore digital pathology images and associated metadata, as well aspatient metadata. When multiple organizations are networked, studiesco-exist in a physicians work queue from both the physician's ownorganization and from secondary organizations (FIG. 3—Review RequestQueue).

The invention processes Study Review Requests to generate Study Reviewsvia a federated system of edge and dispatch nodes. Dispatch nodes areutilized to route a large numbers of study review requests overconstrained networking infrastructure with decreased requirements forbandwidth and minimal user intervention. The invention further defines ameans of addressing, routing, and transactional queue managementrelating to the exchange of studies.

In one preferred embodiment, the Simple Distribution Process, theinitial Study Review Request is generated by the Originating Node, andis sent to the Consuming Node, indicating the presence of an availablestudy on the Originating Node.

This embodiment is a computer-based method of distributing biologicalsample data based on specified study review criteria, both of which areon the Originating Node. On the Originating Node, a Study is generatedbased on the specified study review criteria. Further, a progressivetransmission is prepared. The progressive transmission is based ontransmission of requested subsets of biological sample data, thereby notrequiring the whole of the data to be transmitted. Additionally, basedon the specified study review criteria, a Study Review Request isprepared. The review request is then transmitted to at least oneConsuming Node. In response to a signal from the Consuming Node, thetransmission is streamed in a progressive manner, as a subset, in partor in full, from the Originating Node to the Consuming Node. Thesesubsets are based on the progressive technique employed, and wouldinclude the following non-limiting aspects: spatial regions, scale,tiling, or other common progressive image transmission techniques.

In a second preferred embodiment, the Dispatched Distribution Process,the initial Study Review Request is generated by the Originating Node,and is sent to a Dispatcher Node, which forwards the communications tothe Consuming Node.

This embodiment is a computer-based method of distributing biologicalsample data based on specified study review criteria, both of which areon the Originating Node. On the Originating Node, a Study is generatedbased on the specified study review criteria. Further, a progressivetransmission is prepared. The progressive transmission is based ontransmission of requested subsets of biological sample data, thereby notrequiring the whole of the data to be transmitted. Additionally, basedon the specified study review criteria, a Study Review Request isprepared. The review request is then transmitted to at least oneDispatcher Node. The Study Review Request is then forwarded from theDispatcher Node to a Consuming Node. In response to a signal from theConsuming Node, which is sent to the Dispatcher Node and forwarded tothe Originating Node, the transmission is sent in a progressive manner,as a subset, in part or in full, from the Originating Node to theConsuming Node via the Dispatcher. These subsets are based on theprogressive technique employed, and would include the followingnon-limiting aspects: spatial regions, scale, tiling, or other commonprogressive image transmission techniques.

BRIEF DESCRIPTION OF FIGURES

The foregoing will be apparent from the following more particulardescription of example embodiments of the invention, as illustrated inthe accompanying drawings in which like reference characters refer tothe same parts throughout the different views. The drawings are notnecessarily to scale, emphasis instead being placed upon illustratingembodiments of the present invention.

FIG. 1 shows the Data Structures in the Exchange of Studies. There aresix major data types, composed of two studies (105), which areequivalently known as packages, a Study Review Request (130), StudyReview Acceptance (140) and Study Review Cancellation (150), and a StudyReview (160).

The first package type is a Preview Study (110). The first element ofthe preview study is Preview Study Metadata (111), which includesfiltered or restricted notes of the originator of the study. The secondelement is Restricted Patient Metadata (112), which is comprised ofanonymized patient metadata. The third element is Low-Resolution Images(113) of the Biological Specimen.

The second package type is a Detailed Study (120). The first element ofthe detailed study is Study Metadata (121), which includes the full(unrestricted) notes of the originator of the study. The second elementis Patient Metadata (122), which is comprised of the full (unrestricted)patient metadata. The third element is Additional References (123),which may include references to additional patient metadata, such as thepatient's EMR (Electronic Medical Record) or similar cases, comparableimages or notes which are not specifically from this patient or study.The fourth element is Multi-Resolution Images (114) of the BiologicalSpecimen, which includes zoom-able, progressive access to the WholeSlide Image (equivalently WSI) at different image resolutions(equivalently, zoom levels).

The next data structure is the Study Review Request (130), which is sentfrom the Originator to the Consumer. The first element of the reviewrequest is a Preview Study (110). The second element is a Detailed StudyReference (131), which provides the necessary information to access thedetailed study. The third element is the Recipient List & Policies(132), which includes study priority, expiration, cardinality, routinginformation or other policy details.

The fourth data structure is the Study Review Acceptance (140). Thismessage is sent in response to the review request (130), and notifiesthe originator of the review request of the consumer's acceptance orrejection of the Study Review Request.

The fifth data structure is the Study Review Cancellation (150). Thismessage is sent to consumers in the event of a manual reviewcancellation by the originator, due to a Study Review Request'sexpiration, or due to the review request meeting its conditions by otherconsumers.

The sixth data structure is the Study Review (160). The first element isa Pathology Review (161), which includes text, verbal or other notes anddiagnosis from the Consumer. The second element is Pathology ReviewMetadata (162), which may include details of the pathology reviewsession, measurements or other data. The third element is PathologyReview Annotations (163), which may include notes and a point or regionbased annotation at a specific location (location and resolution) of aMulti-Resolution Image (114). The fourth element is Pathology ReviewSub-Images or External Reference Images (164), which may containsub-images from the Multi-Resolution Images (114) of the detailed study,or references to images outside of the study which are comparable orsupportive of the Pathology Review.

FIG. 2 depicts the node, organizations and router types in a digitalpathology system, and the organization configurations which can becreated using those node and routers. The first node type is anOriginating Node (210), equivalently referred to as the Originating Useror Originator Node, which creates packages (105) and Study ReviewRequests (130). The second node type is a Consuming Node (220),equivalently referred to as a Target User or Consumer Node, for which areview request is assembled and assigned, and which generates a StudyReview (140) which is returned to the Originator.

An Organization (230) is a grouping of one or more Originating Nodes(210), Consuming Nodes (220) and an Edge Dispatcher (240). Anorganization represents a logical entity which produces, consumes orboth produces and consumes packages.

The first of the two router types is an Edge Dispatcher (240). The EdgeDispatcher is responsible for routing the package (105) from theOriginating Node (210) to the Consuming Node (220). In the simplest ofembodiments, both of nodes and the edge dispatcher exist within the sameOrganization, and may be the same User. The second router type is theGlobal Dispatcher (250), which is used to route and federate packages(105) between organizations (230). The edge dispatcher of theoriginating organization will route a package through a globaldispatcher to the edge dispatcher of the consuming organization.

The various Nodes and Edge Dispatchers can be combined into a set ofdifferent organization. The first example organization is an OriginatingOrganization (231), which contains one or more Originating Nodes (210)and an Edge Dispatcher (240). This second example organization is aConsuming Organization (232), which contains one or more Consuming Nodes(220) and an Edge Dispatcher (240). The final example organization is anOriginating and Consuming Organization (233), which contains one or moreOriginating Nodes (210), one or more Consuming Nodes (220) and an EdgeDispatcher (240).

FIG. 3 depicts the Study Queue of an Organization. In an organizationwith a Consuming Node (210), there is a Study Work Queue (310). Thestudy work queue contains both Internal Study Review Requests (320) andExternal Study Review Requests (330). An internal Study Review Requestis a review request which is generated within the same organization asthe consuming node. An external Study Review Request is a review requestwhich is generated by a different organization from the consuming node.

FIG. 4 is an overview of the major components required to processStudies (both Preview Studies and Detailed Studies) from a) anorganization to itself, b) from a consumer only site, c) to a peerorganizations through a global dispatcher.

In the first embodiment, a Review Request is generated within anOrganization (401) which is an Originating and Consuming Organization(233), containing an Originating Node (210), a Consuming Node (220), andan Edge Dispatcher (240). The Originating Node is comprised of bothImage Services (411) and Metadata Services (412). First, a Study ReviewRequest (130) is sent from the Originating Node's Metadata Services tothe Consuming Node (421). A Study Review Acceptance (140) message issent from the Consumer to the Image Services (423). The Consumer hasaccess to the Detailed Study (120) images from the Image Services (422),and the metadata from the Metadata Services (421). Finally, a StudyReview (160) is sent from the Consumer to the Originator's MetadataServices.

In the second embodiment, a Study Review Request is generated from anorganization that provides remote metadata and image acquisition for theoriginating organization. The remote Organization (403), which containsan Originating Node (210), creates studies for review by an Organization(401), which is an Originating and Consuming Organization (233), andcontains an Originating Node (210), a Consuming Node (220), and an EdgeDispatcher (240). The Originating Node is comprised of both ImageServices (411) and Metadata Services (412). First, a Study ReviewRequest (130) is sent from the Originating Node's Metadata Services tothe Consuming Node's Metadata Services(431). The Consuming Node can thenaccess the Study Review Request directly from their local MetadataServices (421). A Study Review Acceptance (140) message is sent from theConsumer to the Image Services (423), which is forwarded to theOriginator's Metadata Services (433). The Consumer has access to theDetailed Study (120) images directly from the Image Services (432) ofthe Originating Node, and the metadata from the Metadata Services (421).Finally, a Study Review (160) is sent from the Consumer to theOriginator's Metadata Services (433) via the Consumer's local MetadataServices (423).

In the second embodiment, a Study Review Request is generated from anorganization that provides remote metadata and image acquisition for theoriginating organization. The remote Organization (403), which containsan Originating Node (210), creates studies for review by an Organization(401), which is an Originating and Consuming Organization (233), andcontains an Originating Node (210), a Consuming Node (220), and an EdgeDispatcher (240). The Originating Node is comprised of both ImageServices (411) and Metadata Services (412). First, a Study ReviewRequest (130) is sent from the Originating Node's Metadata Services tothe Consuming Node's Metadata Services(431). The Consuming Node can thenaccess the Review Request directly from their local Metadata Services(421). A Study Review Acceptance (140) message is sent from the Consumerto the Image Services (423), which is forwarded to the Originator'sMetadata Services (433). The Consumer has access to the Detailed Study(120) images directly from the Image Services (432) of the OriginatingNode, and the metadata from the Metadata Services (421). Finally, aStudy Review (160) is sent from the Consumer to the Originator'sMetadata Services (433) via the Consumer's local Metadata Services(423).

In the third embodiment, a Study Review Request is generated from anOriginating and Consuming Organization (401) to a peer ConsumingOrganization (403). A Study Review Request is sent from the OriginatingOrganization to the Consuming Organization. This message is routed (441)from the Metadata Services (412) through the Originator's EdgeDispatcher, which is then routed (442) to the Global dispatcher, whichis then routed (443) to the Consumer's Edge Dispatcher, which is thenrouted (444) to the Consuming Node. The Study Review Acceptance messageis then routed from the Consuming Node to the Edge Dispatcher (446),then to the Global Dispatcher (447), then to the Originator's EdgeDispatcher (448), before being routed to the Originating Node (449). TheDetailed Study (120) image access is direct (445) from the ImageServices (411), with the Detailed Study metadata coming via the Edge andGlobal Dispatchers (441-442-443-444). Finally, the Study Review (160) isrouted from the Consuming Node to the Originating Node via the Edge andGlobal Dispatchers (446-447-448-449).

FIG. 5 depicts the Message Exchange for a Single Consumer Review. Asingle consumer review involves a single Originating Node (210), asingle Consuming Node (220), and a single Edge Dispatcher (240).

Initially, the Originating Node (210) assembles a Preview Study (110)and a Detailed Study (120). It then packages the Preview Study and areference to the Detailed Study into a Study Review Request (130), whichis sent to the Consuming Node (220) via the Edge Dispatcher (240). TheConsuming Node receives the Review Request, evaluates it, and sends aStudy Review Acceptance (140) message back to the Originator via theEdge Dispatcher, designating the Study as accepted, and the ConsumingNode as the Assigned Node. At this point, the Consuming Node has accessto the Detailed Study (120) via the Edge Dispatcher. Finally, uponcompletion of the Consuming Node's review, the Consuming Node submitsits Study Review (160) to the Originator, via the Edge Dispatcher.

FIG. 6 depicts the Message Exchange for a Review from MultipleConsumers. A multi-consumer review involves a single Originating Node(210), two or more Consuming Nodes (220), and a single Edge Dispatcher(240).

Initially, the Originating Node (210) assembles a Preview Study (110)and a Detailed Study (120). It then packages the Preview Study and areference to the Detailed Study into a Study Review Request (130), whichis sent to all Consuming Nodes (220) via the Edge Dispatcher (240). EachConsuming Node receives the Review Request and has the opportunity toevaluate it. The first Consuming Node to evaluate the review request andsend a Study Review Acceptance (140) message back to the Originator viathe Edge Dispatcher is designated the Assigned Node, and the Study isdeemed Accepted. If the Cardinality of the Study Review Request has beenmet, a Study Review Cancellation (150) message is sent to the remainderof the Consuming Nodes. At this point, the Consuming Node which hasaccepted the study has access to the Detailed Study (120) via the EdgeDispatcher. Finally, upon completion of the Consuming Node's review, theConsuming Node submits its Study Review (160) to the Originator, via theEdge Dispatcher.

FIG. 7 depicts Embodiments of Messaging Routing Paths, which is anon-limiting example of routing configurations between a singleOriginating Node (210) and a single Consuming Node (220).

In the first example, Simple Originator-Consumer (710), a Study ReviewRequest (130) is generated and sent from the Originating Node (210)directly to the Consuming Node (220). The Consuming Node responds with aStudy Review Acceptance (150) message to the Originating Node. TheConsuming Node then has direct access to the Detailed Study (120) fromthe Originator. Finally, the Consuming Node responds to the OriginatingNode with a Study Review (160).

In the second example, Originator-Consumer through Edge Dispatcher(720), a Study Review Request (130) is generated and sent from theOriginating Node (210) to the Consuming Node (220) via an EdgeDispatcher (240). The Consuming Node responds with a Study ReviewAcceptance (150) message to the Originating Node via an Edge Dispatcher.The Consuming Node then has access to the Detailed Study (120) from theOriginator via an Edge Dispatcher. Finally, the Consuming Node respondsto the Originating Node with a Study Review (160) via an EdgeDispatcher.

In the third example, Originator-Consumer through Edge Dispatcher withDirect Detailed Study (730), a Study Review Request (130) is generatedand sent from the Originating Node (210) to the Consuming Node (220) viaan Edge Dispatcher (240). The Consuming Node responds with a StudyReview Acceptance (150) message to the Originating Node via an EdgeDispatcher. The Consuming Node then has direct access to the DetailedStudy (120) from the Originator. Finally, the Consuming Node responds tothe Originating Node with a Study Review (160) via an Edge Dispatcher.

In the fourth example, Originator-Consumer through Edge and GlobalDispatchers (740), a Study Review Request (130) is generated and sentfrom the Originating Node (210) to the Consuming Node (220) via an EdgeDispatcher (240) associated with the Originator, a Global Dispatcher(250), and a second Edge Dispatcher (240) associated with the Consumer.The Consuming Node responds with a Study Review Acceptance (150) messageto the Originating Node via its associated Edge Dispatcher, through theGlobal Dispatcher, and through the Originator's Edge Dispatcher. TheConsuming Node then has access to the Detailed Study (120) from theOriginator via both Edge Dispatchers and the Global Dispatcher. Finally,the Consuming Node responds to the Originating Node with a Study Review(160), first through its Edge Dispatcher, the Global Dispatcher, andfinally through the Originator's Edge Dispatcher.

In the fifth example, Originator-Consumer through Edge and GlobalDispatchers (740), a Study Review Request (130) is generated and sentfrom the Originating Node (210) to the Consuming Node (220) via an EdgeDispatcher (240) associated with the Originator, a Global Dispatcher(250), and a second Edge Dispatcher (240) associated with the Consumer.The Consuming Node responds with a Study Review Acceptance (150) messageto the Originating Node via its associated Edge Dispatcher, through theGlobal Dispatcher, and through the Originator's Edge Dispatcher. TheConsuming Node then has access to the Detailed Study (120) directly fromthe Originator. Finally, the Consuming Node responds to the OriginatingNode with a Study Review (160), first through its Edge Dispatcher, theGlobal Dispatcher, and finally through the Originator's Edge Dispatcher.

FIG. 8 is a schematic view of a computer network environment in whichembodiments of the invention are deployed.

FIG. 9 is a block diagram of a computer node of the network of FIG. 8.

DESCRIPTION OF THE INVENTION

Elements of the invention include several combinations of study datastructures and node types. There are roughly six types of study datastructures: Preview Study, Detailed Study, Study Review Request, StudyReview Acceptance, Study Review Cancelation, Study Review. The nodetypes include two primary node types and two router node types:Consuming Node, Originating Node, Edge Dispatcher, and GlobalDispatcher.

Preview Study

The first of the five major data structures is the Preview Study (FIG.1-110), which contains one or more samples of the study images whichprovide a survey of the study images, combined with both image andpatient metadata. The preview study is intended to provide sufficientdata to make a decision on further routing of the review request, orenable a decision on whether to fulfill (accept) a review request.

Detailed Study

The second major data structure is the Detailed Study (FIG. 1-120),which consists of one or more progressively-rich resolution imagescombined with additional metadata. A set of preferred embodiments is toprovide access to a plurality of image tiles or a stream of image tilesproviding on-demand access to regions (x, y, & z locations andmagnification) of the images as they are viewed by the consuming node. Asecond preferred embodiment is to push or pull the entire image from theoriginating node to the consuming node, caching the image for futureconsumption. The metadata may also be realized in a progressive manner,by providing on-demand access to additional patient metadata that isrelated to but not contained within the study itself (such as but notlimited to additional patient history, results of previous pathologystudies, non-pathological study results, detailed studies other than thecurrent study).

Study Review Request

The third major data structure is the Review Request (FIG. 1-130), whichcontains the Preview Study, a reference to the Detailed Study, as wellas addressing and routing information, and any policies and constraintson the study, such as (but not limited to) priority, expiration,expiration after acceptance, reimbursement rates, and number ofauthorized reviews.

Study Review Acceptance

The fourth major data structure is the Study Review Acceptance,equivalently acceptance message (FIG. 1-140), which is returned by theconsuming node to the originating node in response to a Review Requestand Preview Study. The acceptance message signals either the acceptanceor rejection of the review request by the consuming node. In the eventof an acceptance message, if the review request included a plurality ofconsuming nodes, if the review request's cardinality (number ofrequested reviews) has been met, a “broadcast acceptance” message issent to all remaining consuming nodes. This message signals that thereview request has been conditionally fulfilled and that no additionalacceptance messages will be processed for the review request. In apreferred embodiment, the Preview Study remains cached on the consumingnode for the duration of the contention lock of the review requestacceptance. If the lock expires, the Review Request is once againforwarded to the remaining recipients for processing.

Study Review Cancellation

The fifth major data structure is the Study Review Cancellation message(FIG. 1-150), which is sent by the originating node or a dispatcher. TheStudy Review Cancellation message is sent in response to a number ofcircumstances, including but not limited to: cancellation of the reviewrequest by the originating, expiration of lease time for a review,meeting the cardinality of a review request in a Multiple ConsumerReview Request (FIG. 6).

Study Review

The final major data structure is the Review (or Diagnosis) (FIG. 1-160)which is returned by the consuming node to the originating node, whichmay contained a detailed written or audio diagnosis, a series ofannotations (x, y, & z locations, zoom factors and notations) or images,as well as review metadata, which may contain, but is not limited to,physician metadata, review date & time, duration of review, and detailof what elements of the Detailed Study were consumed.

Originating Node

Originating nodes, equivalently originator nodes (FIG. 2-210), are theend-points which allow for the creation of Preview Studies, DetailedStudies and Review Requests. Originating nodes address the study to oneor more consuming nodes for review. Originating nodes also processReviews generated by consuming nodes in response to a Review Request. Ina preferred embodiment, the originating node coordinates with an edgedispatcher to route the study to the intended consuming nodes.

Consuming Node

Consuming nodes, equivalently consumer nodes (FIG. 2-220), processreview requests, preview studies and detailed studies to provide areview to an originating node. Consuming nodes initially receive PreviewStudies enabling a study to be accepted or rejected. If accepted, theconsuming node communicates that acceptance (generally through an edgedispatcher), and receives the Detailed Study for review. Once a Reviewhas been created, the Review is committed to the originating node. Inthe preferred embodiment, the consuming node coordinates with an edgedispatcher to route these data structures to the originating node. Whena consuming node accepts or rejects a review request, this acceptance orrejection is signaled to the originating node. In a preferredembodiment, this signaling is routed through a plurality of dispatchers.

Edge Dispatcher

The edge dispatcher (FIG. 2-240) node belongs to a single organization.If an originating node exists within the organization, the edgedispatcher is responsible for addressing and routing studies whichoriginate within the organization to the appropriate consumingorganization's edge dispatcher for review. If a consuming node existswithin the organization, the edge dispatcher receives and manages thequeue of studies to be reviewed by the organization's consuming node. Inboth cases, the edge dispatcher handles studies from internal andexternal organizations in the same manner, merging both local reviewrequests and review requests from external organizations which areintended for the consuming node (FIG. 3).

Global Dispatcher

In networks involving more than a handful of peer organizations, a morecomplex network topology is required. To directly connect the edgedispatcher of an organization in the network to every other edgedispatcher in the network becomes labor intensive as the network grows.Having central nodes for the edge dispatchers to connect to facilitatesthe management of the members of the network, and allows for improvedreliability through having multiple central nodes, providing multiplepaths to organization. Such central nodes are called Global Dispatchers.

The exchange of studies is accomplished through a connection of aplurality of organization nodes with a Global Dispatcher node. TheGlobal Dispatcher node facilitates the connection of new organizationsto the cloud and facilitates the directed exchange of studies to theintended recipients. The network of Organizations connected to a GlobalDispatcher is referred to as a cloud, or a pathology network. The GlobalDispatcher facilitates the exchange of studies through theauthentication and federation of a new organization into the cloud,obviating the need to exchange authentication information with allorganizations which currently exist in the system on an individualbasis.

The global dispatcher (FIG. 2-250) node manages the transfer of datastructures between edge dispatchers, and federates the edge dispatchersand organizations. The global dispatcher's primary function is toreceive study data structures, routing them to the edge dispatcher of aplurality of recipients. When a review request is accepted by aconsuming node, the Global Dispatcher generates a ‘broadcast acceptance’to both the originating node as well as to all additional addressedconsuming nodes of the study. The Global Dispatcher queries the requiredsecurity credentials for the Detailed Study from the originating node,conveying them to the consuming node, providing access to the DetailedStudy through a plurality of means, either directly or through one ormore dispatcher nodes.

Discussion of Node & Network Topologies

The digital pathology system from which the study originates is termedthe originating node. Likewise, the digital pathology system receivingthe study and providing a review is termed the consuming node. The nodesthemselves are considered to have one or more networked computationalunits having a variety of designs.

A networked computational element is an addressable endpoint in anetwork that can perform a computational task. The endpoint, or node,may be simply a networked computer, a cluster of networked servers, avirtual server within a pooled set of server resources, one of a set ofvirtual servers contained on a server, or any combination of hardwareand software that is able to provide a network address along withexecution of the digital pathology system's processing described in thisinvention.

A digital pathology system is a demarcated set of networkedcomputational elements under the administration of a singleorganization. When the originating node and consuming node arecollocated within a single digital pathology system, this is termed anIntra-site digital pathology system, or simply Intra-site. When theoriginating node and consuming nodes each belong to separate digitalpathology systems, and therefore belong to different organizations, thistopology is termed an Inter-site digital pathology system, or simplyInter-site. One characteristic difference between Intra-site andInter-site is the network topology. Intra-site will tend to havegeographically co-located networked computational elements, anddedicated high speed connections between geographically disparatenetworked computation elements. Inter-site network topologies will tendto have more ad hoc connections that would utilize combinations ofnon-dedicated or on-demand network infrastructures, typically resultingin a less controlled, more variable performance relative to theIntra-site network topology, which generally utilizes moreover-provisioned and controlled resources.

In a preferred embodiment, an Intra-site Network Topology is utilized,with both the originating node and the consuming node within the sameorganization (site). A study is created by the organization'soriginating node, addressed to the organization itself, and is reviewedby the organization's consuming node, and is generally routed throughand queued by a local edge dispatcher. Without loss of generality, theoriginating and consuming nodes may exist on the same LAN or WAN, or maybe connected via VPN or other tunneling technologies.

In a second preferred embodiment, an Inter-site Network Topology isutilized, with the originating node and the consuming node withindifferent organizations (sites). A study is created by oneorganization's originating node, addressed to a second organization, andis reviewed by the second organization's consuming node, generallyrouted through a plurality of edge and global dispatcher nodes. Withoutloss of generality, the two organizations may be connected to oneanother via a dedicated circuit, VPN, the Internet or any other networktechnologies. Both of these Intra-site and Inter-site embodiments havefurther embodiments allowing a plurality of network topologies betweenan originating and consuming organization, spanning multiple Intra-siteand Inter-site networks in order to properly route and deliver a requestfor review to the consuming organization. This plurality of networks andorganizations comprises today's hospitals, clinics, private practicesand expert centers, as well as future organization types such as ahealthcare cooperatives and virtual practices.

Discussion of Organizations

An organization (FIG. 2-230) is a logical entity representing anoriginator, a consumer, or an originator and consumer of studies.

Examples of an organization that acts as an originator (FIG. 2-231)would be a clinic or private practice unable to provide pathologyservices or hospital without a particular subspecialty. An organizationacting as an originator contains an Originating Node (210) and an EdgeDispatcher Node (240).

Examples of an organization that only acts as a consumer (FIG. 2-232)would be an expert center or virtual practice. An organization acting asa consumer contains a Consuming Node (220) and an Edge Dispatcher Node(240).

Examples of an organization which is both an originator and a consumer(FIG. 2-233) would be a large clinic or hospital providing allsubspecialties. Such an organization would contain an Originating Node(210), a Consuming Node (220) and an Edge Dispatcher Node (240).

An originating organization generates studies and review requests, and aconsuming organization fulfills review requests. In the preferredembodiment the organization is able to both originate and consumestudies, and contains both an originating node and a consuming node. Thepreferred embodiment of any of these systems also includes an edgedispatcher to facilitate the queuing and routing of review requests fromthe originating node to the consuming node.

Discussion of Dispatchers & Embodiments

The present invention introduces two logical elements into the digitalpathology systems for the purpose of controlling and synchronizing theflow of data among the digital pathology systems' networkedcomputational elements. These two logical elements are termeddispatchers; there is both an edge dispatcher and a global dispatcher.The edge dispatcher is responsible for dispatching services for adiscretely isolated digital pathology system, and this dispatcher isused to demarcate that system. An edge dispatcher may be connected to apeer edge dispatcher, or may be connected through a global dispatcher toa plurality of edge dispatchers. The global dispatcher provides similarfunctionality as the edge dispatcher with additional functionalityrequired to coordinate between and federate two or more edgedispatchers. Once an edge dispatcher node is connected to a globaldispatcher node, that edge dispatcher may address and route reviewrequests to all nodes directly or indirectly connected to the globaldispatcher node.

In one embodiment, an originating organization contains at least an edgedispatcher and either an originating node or a consuming node.

Another embodiment includes a digital pathology solution where theoriginating node provides the preview study, review request and detailedstudy directly to the consuming node, and receives study acceptance anddiagnosis directly from the consuming node (FIG. 7-710). In a set offurther, non-limiting embodiments, an edge dispatcher may be added toroute and queue all of the aforementioned data structures (FIG. 7-720),and a global dispatcher may be added to both route and queue all of thedata structures between edge dispatchers (FIG. 7-740). Additionally, oneor more of the data structure paths may be designed to bypass one or allof the intermediate routing nodes, as exemplified by the directdistribution of the detailed study from originator to consumer,bypassing the first the edge dispatcher (FIG. 7-730), and likewisebypassing both edge dispatchers and the global dispatcher (FIG. 7-750).

When an organization containing an originating node is connected toexternal dispatchers, that node has joined an Inter-site NetworkTopology. The organization may act as an originator of studies to bothits own organization and any other organization with a dispatcher thatis connected via any series of connections.

When an organization containing a consuming node is connected toexternal dispatchers, that node has joined an Inter-site NetworkTopology. That organization may now act as a consumer of studies bothfrom its own organization and from any other organization with aconnected dispatcher. In this case, an edge dispatcher located withinthe same organization as the consuming node is used to route and queueboth local and external review requests to the consuming node (FIG. 3).

One embodiment of the invention is a means of processing study reviewrequests through a federated system of dispatch nodes through theinclusion of a Global Dispatcher, which is connected to a plurality ofedge dispatchers. Such routing facilitates routing a large numbers ofreview requests over constrained networking infrastructure (constrainedin bandwidth, security, information privacy) with little or no userintervention. The Global Dispatcher node enables the addressing anddistribution of studies from an originating node to one or morereceiving nodes. The method further comprises the addressing, routing,and transactional queue management of a plurality of user nodes anddispatcher nodes. The present invention allows a plurality ofinterconnected Organizations, which are equivalently referred to asorganization nodes, to combine with expert centers representing many ofthe major hospitals around the world for the purpose of providingPathology Reviews. Organization nodes with requirements for a secondopinion or an expert opinion on a study, possibly from an expert centerhaving been defined as accepting studies requiring a subspecialtydiagnostic service that is not provided by locally represented worknodes will provide an option of selecting the required service from anyconnected organization node, physician node, or Virtual Practicefederation of nodes.

Through the addressing and routing of study data to multiple qualifiedorganization nodes (FIG. 6) within the cloud, the originatingorganization node increases the redundancy of destination nodes that canfulfill the requested study review service. Further, the latency ofservice fulfillment is potentially decreased by multiple service requestsubmissions. Organization nodes can be defined as qualified though aprocess of vetting. The vetting process provides for the inclusion andsummary of user supplied analysis. In one embodiment, the criteria arederived from the criteria hospitals uses for non-digital second opinionsand referrals. By addressing the study service request to a set of twoor more qualified organization nodes, the qualified organization nodewith a status indicating it is has available resources will be requestedat a higher priority to respond and provide a diagnostic service. Theset/collection may contain any combination of individual nodes,organization nodes or virtual practice nodes from the cloud dispatcher.When the study is assigned to the collection, all consuming nodes thatare addressed for receipt, receive notifications of the assignment forservice fulfillment.

Subsequent to the Review Request, the study is rendered in a viewablestate in the consuming node's available work queue. The first consumingnode to indicate that review service has been completed and that theacceptance state of the work order has been set for the study will causethe consuming node to perform a method that will remove the case fromthe other consuming nodes' available queues. Subsequently, theoriginating organization node will receive notification that the studyis now in an accepted state, along with data indicating theorganizational node that accepted the study. The consuming node thatsets the study in the accepted state creates a contention lock thatincludes an expiration time. This time indicates how long the consumingnode will retain the lock on the acceptance state of the study. Further,the lock provides an exclusive time period during which the consumingnode will be able to review the study and commit a review by submittingthe diagnosis, annotations and additional references back to theoriginating node. Upon completion of these processes, the study will bemarked as being in a completed state. If the lock expires prior to thenotification that the diagnosis data is set, the study will be returnedto the available work queue for all consuming nodes.

In order to ensure that individual nodes, virtual practice nodes, andorganization nodes are associated with the highest possible quality ofservice, various metrics and ratings data may be recorded. These metricsare provided, in one embodiment, by system users, specifically doctorsassociated with the organization nodes. Ratings may include the servicefulfillment time which is calculated as the time from acceptance tocommitting a diagnosis. Additionally the ratings may include the numberof expired cases, the viewed spatial extent of the image, viewingresolutions, and peer quality ratings of the diagnoses (agree/disagreewith diagnosis, quality of diagnosis write-up). A process is definedthat utilizes the ratings in order to define an individual node ororganization node as being excluded from a recipient list. In oneembodiment, a particular individual node or organization node may berated as providing unsatisfactory diagnoses or repeatedly accepts andsubsequently allows a study to expire, and/or delaying the workflow of astudy beyond a predefined study time review limit.

Virtual Practices

Virtual Practices are a specific embodiment of a Consuming Organization(232) consisting of one or more physicians (Consuming Nodes). TheVirtual Practice is created within a Cloud Pathology Network. VirtualPractice nodes may have defined a data attribute indicating if the nodecan service specific or general subspecialty care requests. Such aVirtual Practice node will generally be made up of expert nodescorresponding to specific field services or subspecialty services. Whenimplemented in a cloud computing environment, the advertised fieldinformation provides a means for the node to promote itself as beingdefined as the node having the attribute of being the primary orsecondary node for dispatching at a higher priority than similar nodes.

Virtual practice organizations are logical organizations consisting ofone or more originating or consuming nodes which exist beyond a physicallocation, sharing a single edge dispatcher. Whereas most expert centersand hospitals have a single physical presence, a virtual practiceconsists of a plurality of physically distributed originating orconsuming nodes, whose relationship is only defined in that they areconnected through a common edge dispatcher. The collection of theoriginating or consuming nodes through the dispatcher defines anorganization which offers or requires services to the network and whichmay generate Review Requests to the network, or to which Review Requestsmay be addressed. In one embodiment, a virtual practice may be labeledas a premium or subspecialty expert organization node. In anotherembodiment, a virtual practice may be labeled as servicing costconstrained review requests, or deferring cost in conjunction withresearch. In all embodiments, Virtual Practices are created by combiningindividual nodes or organization nodes, such as a network of affiliatedorganizations (e.g., a group of affiliated hospitals). The individualnodes or organization contained within a Virtual Practice Node define aself-policing service group, which are responsible for enforcing theirown membership policies and metrics. Note that the mentioned servicegroup is not required to map to organization node boundaries, andcontrols its own constituency.

Virtual Practice Nodes

In the cloud dispatcher scenario, virtual practice nodes can be definedas providing a specialty service to the organizations within the cloud.In one embodiment, group nodes may be labeled as premium or subspecialtyexpert group nodes. The virtual practices may further be labeled asdiscounted cost or pro-bono group nodes. In yet another embodiment,group nodes are created by individual nodes or organization nodes. Theindividual nodes or organization nodes define a self-policing servicegroup. Note that the mentioned service group is not required to map toorganization node boundaries.

In one embodiment, an expert group node is defined as a type of virtualpractice node containing nodes that have a common subspecialty label.The expert groups allow the addition of expert level member nodes. Asthey are providing expert level services, they must also beself-policing, to make sure that all members are providing the qualityof diagnostic service that they can market, in order to be the expertgroup of choice for a subspecialty.

In one embodiment, discounted service group nodes are defined as acollection of nodes provided as an optional node providing services fororganization nodes that are defined with labels that indicate ‘pricesensitive’ state or ‘less comprehensive insurance’ state or ‘reimbursesat a lower rate’ state. In a further embodiment, Pro-bono service groupnodes are defined in order to provide a patient screening method usingpredefined qualifying metrics to disable service fulfillment.

Lifecycle of a Study

In any embodiment of a pathology system, there exists both a studyoriginator and a study consumer. Between these two nodes there exists aseries of exchanges which provide progressive access to both image andmetadata of the study, often times facilitated by one or moredispatchers.

In one simple embodiment (FIG. 5—Message Exchange for a Single ConsumerReview), demonstrating the data communication and transformation betweena single originator and a single consumer, there exists a singleoriginating node (210) and a single consuming node (220) connectedthrough a single edge dispatcher (240). The initial input is thecreation of a study (both Preview Study (110) and Detailed Study (120))by an originating node, followed by the creation of a review request(130), addressing the study to the consuming node. All three of thesestructures exist on the originating node (110), and following theaddressing instructions contained within the Review Request, the Request(containing the Preview Study) would be routed from the Originating Nodethrough the Edge Dispatcher (530) to the Consuming Node (520). Uponreceiving the review request, the consuming node evaluates the reviewrequest and the associated preview study, to determine the type ofAcceptance Message (140) to be sent. Rejection of the Review Requestwould result in a Acceptance Message (140) signaling a rejection beingsent by the consuming node (220) to the edge dispatcher (240), whichwould then be forwarded to the originating node (210). A Rejectionmessage terminates that consuming node's (220) involvement in thecurrent Review Request. The alternative is that the consuming node (220)accepts the Review Request, resulting in an acceptance message (140) tothe Edge Dispatcher (240), who in turn forwards the message to theoriginating node (210). The acceptance message includes necessarysecurity tokens to enable secure access to the Detailed Study (120) (viathe edge dispatcher). The consuming node accesses the desired images andmetadata in a progressive manner until a diagnosis can be made, at whichpoint, a Review message (160) from the consuming node (220) is sent,through the edge dispatcher, to the originating node (210). This actionalso concludes that consuming node's (220) involvement in the ReviewRequest and the Review is complete.

Extensions of this simple embodiment include but are not limited tosending one or more of the messages directly from one end node toanother (FIGS. 7-730 and 7-750) as compared to all messages being routedthrough a dispatcher (FIGS. 7-720 and 7-740), as well as including aplurality of edge and global dispatchers in the communications process(FIGS. 7-740 and 7-750).

An additional embodiment is when an originating node generates a ReviewRequest addressed to one or more of a plurality of qualified consuming(FIG. 6). Through the addressing and routing of a Review Request tomultiple qualified consuming nodes, the latency of service fulfillmentis decreased, as it will be fulfilled by the first consuming node withavailable resources. When the number of consuming nodes providing areview fulfills the cardinality requirements of the review request (inFIG. 6, where one review is requested, when the first consuming nodeaccepts), the review request is fulfilled, and a Study ReviewCancellation message (150) is sent to the remainder of Consuming Nodes.In this manner, the originating node may increase redundancy and speedof review by addressing the review request to a plurality of consumingnodes.

Simple Distribution Process

In a preferred embodiment of the Simple Distribution Process (FIG.7-710), the initial request for Study review is initiated by theOriginating Node signaling the Consuming Node, indicating the presenceof an available study on the Originating Node.

This embodiment is a computer-based method of distributing biologicalsample data based on specified study review criteria, both of which areon the Originating Node (FIG. 7-710-210). On the Originating Node, aStudy (FIG. 1-105) is generated based on the specified study reviewcriteria. Further, a progressive transmission is prepared. Theprogressive transmission is based on transmission of requested subsetsof biological sample data, thereby not requiring the whole of the datato be transmitted. Additionally, based on the specified study reviewcriteria, a Study Review Request (FIG. 1-130) is prepared. The reviewrequest is then transmitted (FIG. 7-710-130) to at least one ConsumingNode (FIG. 7-710-220). In response to a signal from the Consuming Node,the transmission is streamed (FIG. 7-710-120) in a progressive manner,as a subset, in part or in full, from the Originating Node to theConsuming Node. These subsets are based on the progressive techniqueemployed, and would include the following non-limiting aspects: spatialregions, scale, tiling, or other common progressive image transmissiontechniques.

A further embodiment based on the Simple Distribution Process includesspecific data in the Study Review Request. This non-limiting embodimentincludes the Patient Metadata (including patient history, specifics ofthe current study) (FIGS. 1-112 & 1-122), preparation data, and/or imagecapture specifications (FIG. 1-121) in the Study Review Request (FIG.1-130). A yet further embodiment would optionally include the followingdata in the Study Review Request as well (FIG. 1-132): the study requesttype, the cardinality of request, the time of request, the expirationtime of request, a request reimbursement specification, and/or asubspecialty requirements for study review.

In yet a further embodiment of the Simple Distribution Process, theprogressive transmission can also be followed by a Study Review (FIG.5-160) being transmitted from the Consuming Node (FIG. 2-220) to theOriginating Node (FIG. 2-210), the Study Review containing informationbased on a review of the study performed at the Consuming Node.Additionally, the information contained in the Study Review canspecifically be defined as one or more of the following data (FIG.1-162): study review quality control parameters, image qualityassessment information, structural analysis report, morphologicalanalysis report, quantitative analysis report. Further, the diagnosiscan optionally contain (FIG. 1-161): a diagnosis, determination ofpathological condition, a description of the diagnosis, and one or moreof the following: additional text, audio commentary, and/or videocommentary. There is a further embodiment where the Study Reviewincludes derived images (FIG. 1-164) and metadata including: the metricsof tissue characteristics, spatial bounds for regions of interest, andthe results of geometric analysis. The results of geometric analysisincluding one or more of the following: gradient analysis, morphologicalanalysis, edge/curve detection, and texture analysis.

Dispatched Distribution Process

In a preferred embodiment of the Dispatched Distribution Process (FIG.7-720), the initial request for Study review indicating the presence ofan available study on the Originating Node, is initiated by theOriginating Node signaling a Dispatcher Node, which forwards thecommunications to the Consuming Node.

This embodiment is a computer-based method of distributing biologicalsample data based on specified study review criteria, both of which areon the Originating Node (FIG. 7-720-210). On the Originating Node, aStudy (FIG. 1-105) is generated based on the specified study reviewcriteria. Further, a progressive transmission is prepared. Theprogressive transmission is based on transmission of requested subsetsof biological sample data, thereby not requiring the whole of the datato be transmitted. Additionally, based on the specified study reviewcriteria, a Study Review Request (FIG. 1-130) is prepared. The reviewrequest is then transmitted (FIG. 7-720-130) to at least one DispatcherNode (FIG. 7-720-240). The Study Review Request is then forwarded fromthe Dispatcher Node to a Consuming Node (FIG. 7-720-220). In response toa signal from the Consuming Node, which is sent to the Dispatcher Nodeand forwarded to the Originating Node, the transmission is sent (FIG.7-720-120) in a progressive manner, as a subset, in part or in full,from the Originating Node to the Consuming Node via the Dispatcher.These subsets are based on the progressive technique employed, and wouldinclude the following non-limiting aspects: spatial regions, scale,tiling, or other common progressive image transmission techniques.

As a further embodiment of the Dispatched Distribution Process, theDispatch Node is comprised of: a computer network that in sum is able toprovide the equivalent external functionality of the Dispatch Node.

As a further embodiment of the Dispatched Distribution Process, thetransmissions to the Dispatch Node include secure communicationscomprising: authentication of the Originating Node, and authenticationof the Consuming Node.

As a further embodiment of the Dispatched Distribution Process, theDispatch Node provides differential services to a plurality ofOriginating Nodes and Consuming Nodes. These services comprising thefollowing in a non-limiting manner: a prioritization of requestfulfillment based on specified priority, and/or sequencing of requestsbased on defined workflow rules.

As a further embodiment of the Dispatched Distribution Process,signaling and transmitted data may be routed through the Dispatcher ordirectly from a Originating Node to a Consuming Node (FIG. 7-730).

As a further embodiment, the data structures and signaling may betransmitted through a plurality of Dispatcher Nodes (FIGS. 7-740 &7-750).

FIG. 8 illustrates a computer network or similar digital processingenvironment in which the present invention may be implemented.

Client computer(s)/devices 50 and server computer(s) 60 provideprocessing, storage, and input/output devices executing applicationprograms and the like. Client computer(s)/devices 50 can also be linkedthrough communications network 70 to other computing devices, includingother client devices/processes 50 and server computer(s) 60.Communications network 70 can be part of a remote access network, aglobal network (e.g., the Internet), a worldwide collection ofcomputers, Local area or Wide area networks, and gateways that currentlyuse respective protocols (TCP/IP, Bluetooth, etc.) to communicate withone another. Other electronic device/computer network architectures aresuitable.

FIG. 9 is a diagram of the internal structure of a computer (e.g.,client processor/device 50 or server computers 60) in the computersystem of FIG. 8. Each computer 50, 60 contains system bus 79, where abus is a set of hardware lines used for data transfer among thecomponents of a computer or processing system. Bus 79 is essentially ashared conduit that connects different elements of a computer system(e.g., processor, disk storage, memory, input/output ports, networkports, etc.) that enables the transfer of information between theelements. Attached to system bus 79 is I/O device interface 82 forconnecting various input and output devices (e.g., keyboard, mouse,displays, printers, speakers, etc.) to the computer 50, 60. Networkinterface 86 allows the computer to connect to various other devicesattached to a network (e.g., network 70 of FIG. 8). Memory 90 providesvolatile storage for computer software instructions 92 and data 94 usedto implement an embodiment of the present invention (e.g., digitalpathology system operators/engines including pathology study exchangeprocess modules and nodes, and supporting code detailed above). Diskstorage 95 provides non-volatile storage for computer softwareinstructions 92 and data 94 used to implement an embodiment of thepresent invention. Central processor unit 84 is also attached to systembus 79 and provides for the execution of computer instructions.

In one embodiment, the processor routines 92 and data 94 are a computerprogram product (generally referenced 92), including a computer readablemedium (e.g., a removable storage medium such as one or more DVD-ROM's,CD-ROM's, diskettes, tapes, etc.) that provides at least a portion ofthe software instructions for the invention system. Computer programproduct 92 can be installed by any suitable software installationprocedure, as is well known in the art. In another embodiment, at leasta portion of the software instructions may also be downloaded over acable, communication and/or wireless connection. In other embodiments,the invention programs are a computer program propagated signal product107 embodied on a propagated signal on a propagation medium (e.g., aradio wave, an infrared wave, a laser wave, a sound wave, or anelectrical wave propagated over a global network such as the Internet,or other network(s)). Such carrier medium or signals provide at least aportion of the software instructions for the present inventionroutines/program 92.

In alternate embodiments, the propagated signal is an analog carrierwave or digital signal carried on the propagated medium. For example,the propagated signal may be a digitized signal propagated over a globalnetwork (e.g., the Internet), a telecommunications network, or othernetwork. In one embodiment, the propagated signal is a signal that istransmitted over the propagation medium over a period of time, such asthe instructions for a software application sent in packets over anetwork over a period of milliseconds, seconds, minutes, or longer. Inanother embodiment, the computer readable medium of computer programproduct 92 is a propagation medium that the computer system 50 mayreceive and read, such as by receiving the propagation medium andidentifying a propagated signal embodied in the propagation medium, asdescribed above for computer program propagated signal product.

Generally speaking, the term “carrier medium” or transient carrierencompasses the foregoing transient signals, propagated signals,propagated medium, storage medium and the like.

While this invention has been particularly shown and described withreferences to example embodiments thereof, it will be understood bythose skilled in the art that various changes in form and details may bemade therein without departing from the scope of the inventionencompassed by the appended claims.

1. A computer-based method of distributing biological sample data,comprising: a biological sample data on an Originating Node; and, aspecified Study Review Criteria on the Originating Node; and, processingto generate a Study on the Originating Node based on the Study ReviewCriteria; Study generation processing comprising preparation of aprogressive transmission form of the biological sample data; progressivetransmission form further comprised of one or more subsets of biologicalsample data prepared based on a Study Review Criteria; subset generationprocessing utilizing common progressive image transmission techniques;progressive image transmission techniques including, but not limited todefined spatial regions, scale, or tiling; a first transmission in thedistribution process comprising the Study Review Request from theOriginating Node to a Consuming Node; signaling from the Consuming Nodeto request Study transmission from the Originating Node; a secondtransmission in the distribution process from the Originating Node tothe Consuming Node, including the progressive transmission Study in partor in full form.
 2. A method as claimed in claim 1, wherein the ReviewRequest includes one or more of the following data: a patient history,preparation data, image capture specifications.
 3. A method as claimedin claim 2, wherein the Review Request additionally includes one or moreof the following data: review request information; including one or moreof the following data: review request type, cardinality of request, timeof request, expiration time of request, request reimbursementspecification, subspecialty requirements for study review.
 4. A methodas claimed in claim 1, wherein the second transmission is followed by astudy review, comprising: generation and transmission of a study reviewfrom the Consuming Node to the Originating Node.
 5. A method as claimedin claim 4, wherein the study review includes one or more of thefollowing data: study review quality control parameters, image qualityassessment, structural analysis report, morphological analysis report,quantitative analysis report, diagnosis.
 6. A method as claimed in claim5, wherein the diagnosis comprises: determination of pathologicalcondition, and a description of the diagnosis, and one or more of thefollowing: additional text, audio commentary, video commentary.
 7. Amethod as claimed in claim 4, wherein the study review includes derivedimages and metadata comprising: metrics of tissue characteristics, andspatial bounds for regions of interest, and the results of geometricanalysis including one or more of the following: gradient analysis,morphological analysis, edge/curve detection, and texture analysis.
 8. Acomputer-based method of distributing biological sample data,comprising: a biological sample data on an Originating Node; and, aspecified Study Review Criteria on the Originating Node; and, processingto generate a Study on the Originating Node based on the Study ReviewCriteria; Study generation processing comprising preparation of aprogressive transmission form of the biological sample data; progressivetransmission form further comprised of one or more subsets of biologicalsample data prepared based on a Study Review Criteria; subset generationprocessing utilizing common progressive image transmission techniques;progressive image transmission techniques including, but not limited todefined spatial regions, scale, or tiling; a first transmission in thedistribution process comprising the Study Review Request from theOriginating Node to at least one Dispatcher; signaling the Study ReviewRequest from the Dispatcher to at least one Consuming Node; signalingfrom the Consuming Node to request Study transmission from theDispatcher; signaling the Study transmission request from the Dispatcherto the Originating Node; a second transmission in the distributionprocess from the Originating Node to the Consuming Node, consisting ofthe progressive transmission Study in part or in full form.
 9. A methodas claimed in claim 8, wherein the Dispatch Node is comprised of: acomputer network that in sum is able to provide the equivalentfunctionality of the Dispatch Node.
 10. A method as claimed in claim 8,wherein the transmissions to the Dispatch Node include securecommunications comprising: authentication of the Originating Node, andauthentication of the Consuming Node.
 11. A method as claimed in claim8, wherein the Dispatch Node provides differential services to aplurality of Originating Nodes and Consuming Nodes, services comprising:a prioritization of request fulfillment based on specified priority, andsequencing of requests based on defined workflow rules.
 12. A method asclaimed in claim 8, wherein the second transmission in the distributionprocess consists of the progressive transmission Study in part or infull form from the Originating Node to the Dispatcher, and then from theDispatcher to the Consuming Node.